diff --git a/lib/compress.js b/lib/compress.js
index 5bc633b0..b0da1b5e 100644
--- a/lib/compress.js
+++ b/lib/compress.js
@@ -8345,6 +8345,9 @@ Compressor.prototype.compress = function(node) {
                     var dropped = value.drop_side_effect_free(compressor);
                     if (dropped !== value) {
                         changed = true;
+                        if (dropped && async && !is_primitive(compressor, dropped)) {
+                            dropped = dropped.negate(compressor);
+                        }
                         node.value = dropped;
                     }
                 }
diff --git a/test/compress/awaits.js b/test/compress/awaits.js
index c527cc07..f229c266 100644
--- a/test/compress/awaits.js
+++ b/test/compress/awaits.js
@@ -3001,3 +3001,37 @@ issue_5456: {
     expect_stdout: "foo"
     node_version: ">=8"
 }
+
+issue_5478: {
+    options = {
+        side_effects: true,
+    }
+    input: {
+        A = {
+            get then() {
+                a = "FAIL";
+            },
+        };
+        var a = "PASS";
+        (async function() {
+            for (var b in "foo")
+                return void A;
+        })();
+        console.log(a);
+    }
+    expect: {
+        A = {
+            get then() {
+                a = "FAIL";
+            },
+        };
+        var a = "PASS";
+        (async function() {
+            for (var b in "foo")
+                return !A;
+        })();
+        console.log(a);
+    }
+    expect_stdout: "PASS"
+    node_version: ">=8"
+}