diff --git a/lib/compress.js b/lib/compress.js
index be9b718a..a25c3d66 100644
--- a/lib/compress.js
+++ b/lib/compress.js
@@ -6847,7 +6847,14 @@ Compressor.prototype.compress = function(node) {
                     });
                 }
             }
-            if (node instanceof AST_Call) calls_to_drop_args.push(node);
+            if (node instanceof AST_Call) {
+                calls_to_drop_args.push(node);
+                node.args = node.args.map(function(arg) {
+                    return arg.transform(tt);
+                });
+                node.expression = node.expression.transform(tt);
+                return node;
+            }
             if (scope !== self) return;
             if (drop_funcs && node !== self && node instanceof AST_DefClass) {
                 var def = node.name.definition();
diff --git a/test/compress/rests.js b/test/compress/rests.js
index 98a640e8..056d8c8a 100644
--- a/test/compress/rests.js
+++ b/test/compress/rests.js
@@ -1323,3 +1323,43 @@ issue_5370: {
     expect_stdout: true
     node_version: ">=6"
 }
+
+issue_5391: {
+    options = {
+        evaluate: true,
+        keep_fargs: false,
+        objects: true,
+        pure_getters: "strict",
+        reduce_vars: true,
+        side_effects: true,
+        toplevel: true,
+        unused: true,
+    }
+    input: {
+        var a, b = function f({
+            p: {},
+            ...c
+        }) {
+            while (c.q);
+        }({
+            p: {
+                r: a++,
+                r: 0,
+            }
+        });
+        console.log(a);
+    }
+    expect: {
+        (function({
+            p: {},
+            ...c
+        }) {
+            while (c.q);
+        })({
+            p: 0,
+        });
+        console.log(NaN);
+    }
+    expect_stdout: "NaN"
+    node_version: ">=8.3.0"
+}