diff --git a/lib/compress.js b/lib/compress.js
index 80ace965..6f4d46fc 100644
--- a/lib/compress.js
+++ b/lib/compress.js
@@ -4767,6 +4767,7 @@ Compressor.prototype.compress = function(node) {
         });
         var scan_modified = new TreeWalker(function(node) {
             if (node instanceof AST_Assign) modified(node.left);
+            if (node instanceof AST_ForEnumeration) modified(node.init);
             if (node instanceof AST_Unary && UNARY_POSTFIX[node.operator]) modified(node.expression);
         });
         function modified(node) {
diff --git a/test/compress/evaluate.js b/test/compress/evaluate.js
index d6e2867d..0f8cfaf6 100644
--- a/test/compress/evaluate.js
+++ b/test/compress/evaluate.js
@@ -3349,3 +3349,30 @@ issue_5362_2: {
     }
     expect_stdout: "true"
 }
+
+issue_5380: {
+    options = {
+        evaluate: true,
+        keep_fnames: true,
+        reduce_vars: true,
+        toplevel: true,
+        unused: true,
+    }
+    input: {
+        var a = function f(b) {
+            return function g() {
+                for (b in { PASS: 42 });
+            }(), b;
+        }("FAIL");
+        console.log(a);
+    }
+    expect: {
+        var a = function f(b) {
+            return function g() {
+                for (b in { PASS: 42 });
+            }(), b;
+        }("FAIL");
+        console.log(a);
+    }
+    expect_stdout: "PASS"
+}